With a Deadpool spin-off confirmed, the question remains: what is the movie going to be about? Ryan Reynolds told IGN that he hopes the movie will stick as closely to the comic book as possible:
It's tough because when you have a character like Deadpool, to the greatest extent of your power, you want to bring as much authenticity to that character as possible. And by "authenticity," I don't mean that you'd want to make him somebody that you'd have a Starbucks coffee with, I mean that you want to make him as close to the comics as possible. But I'm really happy that the studio is as obsessed with making it as close to the comic book source material as possible. And that's all I really needed to hear.
As for whether Deadpool will have much to do with X-Men Origins: Wolverine, Reynolds said:
Without saying too much, I can't imagine that there's gonna be any tie-in to the Wolverine movie at all. There's that little teaser at the end, but for the most part, I can't imagine that they'd tie it in with the film too closely.
Deadpool will no doubt pull in other characters from the Marvel Universe, and one character Reynolds is really hoping to include is Deadpool's partner Cable. Reynolds told MTV:
That is all being discussed. I'm hoping Cable will be in it. Look, I've made no secret that I love that character. I also love some of the more preliminary characters at the beginning of the series. I like Ajax -- that's an easier character to put in. And Black Tom. I think there's a lot of different villains [we're considering]; you could do a whole bunch of villains, or you could just have Deadpool going up against one guy. We'll see.
Deadpool co-creator Rob Liefield suggested his own story for the movie, which seems to be close to what Reynolds is looking for:
We'll have an adventure with him in the present tense, dressed in his
costume, probably breaking the fourth wall, with some kick-ass action. A past love story, a past spy story, his own story of vengeance -- when he said [in Wolverine] that "I brought swords to my girlfriend's wedding," there's something there.
This past love Liefield suggests could be either the Irish mutant Siryn, niece of the villainous Black Tom, or the assassin Typhoid
Mary, both of whom were romantically involved with Deadpool in the comics. We've got a strong feeling it will be the later, though, since Battlestar Galactica's Katee Sackhoff was recently seen researching the role of Typhoid Mary for an unspecified "Marvel movie."