With the villains for Spider-Man 4 still a mystery, there's one former villain who wouldn't mind returning, and no it's not Willem Dafoe (who showed up in all three previous Spider-Man movies, in one way or another). Alfred Molina, who played Doctor Octopus in Spider-Man 2, told MTV he'd happily come back, though there might be a hurdle or two to climb before it's possible:
No one's mentioned it, and I think it's highly unlikely, seeing as he died.
Sure, Molina died, but death in the comic book universe has a way of not lasting forever:
At the Spider-Man 2 premiere in London, I turned around to one of the producers and said, "It's a real shame that I died, because I would've loved to do another one of these." And he said, "Oh, characters don't die in this universe, they just disappear."
Are there any favorites from Spidey's past that Molina can recommend before screenwriter David Lindsay-Abaire turns in the script and Sony announces who they are?
The only thing I'd like to see is to concentrate on one villain. Having two or three of them sort of dilutes the potency of it.
After the villain overload of Spider-Man 3, fans would probably agree. However, only one villain would likely mean no Doc Ock, meaning no Alfred Molina.